Leveraging structural knowledge to restore the activity of covalently inhibited enzymes

Join us for a live webinar with Dr. Zoran Radić, Adjunct Professor at UC San Diego, for a deep dive into the catalytic core of Acetylcholinesterase and the new perspective on molecular analysis enabled by Virtual Reality.

Atomic details of molecular 3D structures reveal the basis for understanding the catalytic power of enzyme molecules. This is why the correct perception of macromolecular architecture is greatly facilitated by immersive visualization and molecule manipulation in VR.

When offending inhibitors compromise the optimally evolved geometry of enzymes finding out appropriate correcting tools becomes a challenge. Prof. Radić will peek into the active center of one of the most powerful biological catalysts, the enzyme Acetylcholinesterase, and dissect approaches his research team uses to recover enzyme catalytic activity upon covalent modification by some of the most toxic inhibitors, such as Novichok organophosphate poisons.